HRID36027

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(c1ccccc1)n1nnc(-c2ccccc2-c2ccc(CBr)cc2)n1

HCID9980291

未命名化合物

HCID10376290

未命名化合物

PRODUCTS

生成物

结构：CCCCn1c(Cc2ccc(-c3ccccc3-c3nnn(C(C)(C)c4ccccc4)n3)cc2)c(C(=O)O)c2ccccc21

HCID10370781

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

reacting the 4-bromomethyl-2'- [2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl with 2-transmetalated 1-but-1-yl -1H-indole-3-carboxylic acid in the presence of phosphinated palladium catalyst to give 1-butyl-2-[ 2' -(2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl)biphenyl-4ylmethyl]-1H-indole-3-carboxylic acid; and

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2b935097ac7648f99631e18e2526fee6
来源数据集: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05412102
来源说明: uspto-grants-1995_05

反应 SMILES

Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]2[N:16]=[N:17][N:18]([C:20]([CH3:28])([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH3:21])[N:19]=2)=[CH:5][CH:4]=1.[CH2:29]([N:33]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:35]([C:42]([OH:44])=[O:43])=[CH:34]1)[CH2:30][CH2:31][CH3:32]>[Pd]>[CH2:29]([N:33]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:35]([C:42]([OH:44])=[O:43])=[C:34]1[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]2[N:16]=[N:17][N:18]([C:20]([CH3:28])([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH3:21])[N:19]=2)=[CH:5][CH:4]=1)[CH2:30][CH2:31][CH3:32]