HCID 9980291, compound → 1-butyl-2-{2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-ylmethyl}1H-indole-3-carboxylic acid

HRID 36038Notes

Reaction equation

HRID 36038 reaction equation
[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]([OH:16])=[O:15])=[CH:6]1)[CH2:2][CH2:3][CH3:4].Br[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:31]2[N:32]=[N:33][N:34]([C:36]([CH3:44])([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH3:37])[N:35]=2)=[CH:21][CH:20]=1>[Pd]>[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]([OH:16])=[O:15])=[C:6]1[CH2:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:31]2[N:32]=[N:33][N:34]([C:36]([CH3:44])([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH3:37])[N:35]=2)=[CH:23][CH:24]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 9980291HCID 9980291, compoundHCID 103762901-butylindole-3-carboxylic Acid

Product 1

HCID 103707811-butyl-2-{2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-ylmethyl}1H-indole-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

reacting the 2-transmetalated 1-butyl-1H-indole-3-carboxylic acid with 4-bromomethyl-2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl in the presence of phosphinated palladium catalyst to give 1-butyl-2-{2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-ylmethyl}-1H-indole-3-carboxylic acid and

Sources & evidence

ORD record
ord-b473551c7b67407c9f2ae87ebe0f71fc
Source dataset
uspto-grants-1995_05
Patent number
US05412102

Reaction notes

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