HRID36038

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(c1ccccc1)n1nnc(-c2ccccc2-c2ccc(CBr)cc2)n1

HCID9980291

未命名化合物

HCID10376290

未命名化合物

PRODUCTS

生成物

结构：CCCCn1c(Cc2ccc(-c3ccccc3-c3nnn(C(C)(C)c4ccccc4)n3)cc2)c(C(=O)O)c2ccccc21

HCID10370781

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

reacting the 2-transmetalated 1-butyl-1H-indole-3-carboxylic acid with 4-bromomethyl-2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl in the presence of phosphinated palladium catalyst to give 1-butyl-2-{2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-ylmethyl}-1H-indole-3-carboxylic acid and

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b473551c7b67407c9f2ae87ebe0f71fc
来源数据集: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05412102
来源说明: uspto-grants-1995_05

反应 SMILES

[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]([OH:16])=[O:15])=[CH:6]1)[CH2:2][CH2:3][CH3:4].Br[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:31]2[N:32]=[N:33][N:34]([C:36]([CH3:44])([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH3:37])[N:35]=2)=[CH:21][CH:20]=1>[Pd]>[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]([OH:16])=[O:15])=[C:6]1[CH2:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:31]2[N:32]=[N:33][N:34]([C:36]([CH3:44])([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH3:37])[N:35]=2)=[CH:23][CH:24]=1)[CH2:2][CH2:3][CH3:4]