HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 5-Bromo-2-ethyl-7-methyl-1H-imidazo[4,5-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 5-chloro-2-ethyl-7-methyl-3H-Imidazo[4,5-b]pyridine | HCID 19385734 | — |
| Reactant | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| Product | 5-Bromo-2-ethyl-7-methyl-1H-imidazo[4,5-b]pyridine | HCID 19385648 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 5-chloro-2-ethyl-7-methylimidazo[4,5-b]pyridine (22.2 g, 0.113 mol) in 30% HBr-HOAc was heated to 100° C. for 19 h. The mixture was poured onto ice, neutralized with NH4OH, extracted (5×EtOAc), and the organic layers were concentrated to afford 5-bromo-2-ethyl-7-methylimidazo[4,5-b]pyridine as a solid, after crystallization from EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05412097 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-807e95658b95400389c138c923782db3 |
| Source note | uspto-grants-1995_05 |