HRID36120

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7412

Benzoyl chloride

C7H5ClO

结构：CCCc1nc2c(C)c(N)cnc2n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1

HCID19939763

未命名化合物

HCID21974620

未命名化合物

PRODUCTS

生成物

结构：CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1

HCID19939733

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a mixture of 6-amino-7-methyl-2-propyl-3-[2'-(aminosulfonyl)[1,1']-biphenyl-4-yl]methyl-3H-imidazo[4,5-b]pyridine (189 mg, 0.435 mmol) in 14:1 THF/DMF (7.5 mL) at -15° C. was added benzoyl chloride (0.045 mL, 0.392 mmol). The mixture was stirred for 12 h, then 1 mL of MeOH was added and the mixture was o concentrated. Purification (SiO2, 93:3:4 CH2Cl2/MeOH/HOAc) gave the title compound as a solid.

WORKUP

后处理

concentrationconcentrated
customPurification (SiO2, 93:3:4 CH2Cl2/MeOH/HOAc)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ae0560f1471f45d5bc05fcd277e33686
来源数据集: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05412097
来源说明: uspto-grants-1995_05

反应 SMILES

[NH2:1][C:2]1[C:3]([CH3:31])=[C:4]2[N:10]=[C:9]([CH2:11][CH2:12][CH3:13])[N:8]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[S:27]([NH2:30])(=[O:29])=[O:28])=[CH:17][CH:16]=3)[C:5]2=[N:6][CH:7]=1.C1COCC1.CN(C=O)C.[C:42](Cl)(=[O:49])[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1>CO>[C:42]([NH:1][C:2]1[C:3]([CH3:31])=[C:4]2[N:10]=[C:9]([CH2:11][CH2:12][CH3:13])[N:8]([CH2:14][C:15]3[CH:16]=[CH:17][C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[S:27]([NH2:30])(=[O:29])=[O:28])=[CH:19][CH:20]=3)[C:5]2=[N:6][CH:7]=1)(=[O:49])[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1