HCID 70344690, compound → HCID 86753641, compound

HRID 361312Notes

Reaction equation

HRID 361312 reaction equation
[CH2:1]([N:3]([CH2:27][CH3:28])[C:4]([CH:6]1[CH2:12][N:11](CC2C=CC=CC=2)[CH2:10][CH2:9][N:8](CC2C=CC=CC=2)[CH2:7]1)=[O:5])[CH3:2]>C(O)C.[Pd]>[CH2:27]([N:3]([CH2:1][CH3:2])[C:4]([CH:6]1[CH2:12][NH:11][CH2:10][CH2:9][NH:8][CH2:7]1)=[O:5])[CH3:28]

Participants

4

Reactant 1

HCID 70344690HCID 70344690, compound

Product 1

HCID 86753641HCID 86753641, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2.2 g (5.8 mmol) of 1,4-dibenzyl-[1,4]-diazepan-6-carboxylic acid diethylamide are dissolved in 50 ml of ethanol and hydrogenated over 2 h at room temperature and normal pressure in the presence of 0.5 g of 10% palladium on activated charcoal. Filtration over kieselguhr gives an almost colorless filtrate from which [1,4]-diazepan-6-carboxylic acid diethylamide is obtained in the form of a light yellow oil by concentration under vacuum.

Workup

  1. filtrationFiltration over kieselguhr

Sources & evidence

ORD record
ord-d5800e076ab747089edbec4030533ec8
Source dataset
uspto-grants-1999_02
Patent number
US05866562

Reaction notes

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