6-Bromo4-(3-chloro-4-fluoroanilino)quinazoline hydrochloride salt → HCID 22478426, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 5 except that the reaction mixture was heated to reflux for 3 hours, 6-bromo-4-(3-chloro-4-fluoroanilino)quinazoline hydrochloride salt was reacted with di-isopropyl 2-thienylboronate to give 4-(3-chloro-4-fluoroanilino)-6-(2-thienyl)quinazoline in 36% yield, m.p. 205°-208° C.;

Provenance & Evidence