Dichloromethane → HCID 22478394, compound

HRID 361358Notes

Reaction equation

HRID 361358 reaction equation
ClCl.[C:3]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][N:10]=[C:9]2[NH:16][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[C:19]([Cl:24])[CH:18]=1)(=[O:5])[CH3:4].C(Cl)[Cl:26]>C(O)C>[Cl:26][CH2:4][C:3]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][N:10]=[C:9]2[NH:16][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[C:19]([Cl:24])[CH:18]=1)=[O:5]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 24526Chlorine2×HCID 22478431HCID 22478431, compound

Product 1

HCID 22478394HCID 22478394, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Chlorine gas was led into a stirred mixture of 6-acetyl-4-(3-chloro-4-fluoroanilino)-quinazoline (0.11 g), methylene chloride (40 ml) and ethanol (60 ml) and the mixture was cooled to a temperature in the range 20° to 25° C. After 10 minutes the supply of chlorine was stopped and the reaction mixture was stirred at ambient temperature for 1 hour. The mixture was evaporated to give 6-(2-chloroacetyl)-4-(3-chloro-4-fluoroanilino)quinazoline (0.114 g) which was used without further purification.

Workup

  1. temperaturethe mixture was cooled to a temperature in the range 20° to 25° C
  2. customThe mixture was evaporated

Sources & evidence

ORD record
ord-866c7d8d9f5741979638916fc8fdfb7b
Source dataset
uspto-grants-1999_02
Patent number
US05866572

Reaction notes

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