HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Chloromethyl)pyridine hydrochloride → 4-(3-Chloro-4-fluoroanilino)-7-methoxy-6-(3-pyridylmethoxy)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Chloromethyl)pyridine hydrochloride | HCID 23394 | — |
| Reactant | 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-ol | HCID 10471217 | — |
| Product | 4-(3-Chloro-4-fluoroanilino)-7-methoxy-6-(3-pyridylmethoxy)quinazoline | HCID 22478405 | 18% |
Reaction Steps
Using an analogous procedure to that described in Example 32, 4-(3-chloro-4-fluoroanilino)-6-hydroxy-7-methoxyquinazoline was reacted with 3-chloromethylpyridine, hydrochloride salt to give 4-(3-chloro-4-fluoroanilino)-7-methoxy-6-(3-pyridylmethoxy)-quinazoline in 18% yield;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866572 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-8ebc4e0e339b4d5b91f28620ed4e3acd |
| Source note | uspto-grants-1999_02 |