HuagongsheHuagongshe Chemistry Print Report · For research reference only
Di-isopropyl 3-furylboronate → 6-(3-Furyl)-4-[3-methyl-4-(2-pyridylmethoxy)anilino]-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Di-isopropyl 3-furylboronate | HCID 13903463 | — |
| Reactant | 6-Bromo-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline dihydrochloride salt | HCID 22478386 | — |
| Product | 6-(3-Furyl)-4-[3-methyl-4-(2-pyridylmethoxy)anilino]-quinazoline | HCID 22478425 | 55% |
Reaction Steps
Using an analogous procedure to that described in Example 5, 6-bromo-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline dihydrochloride salt was reacted with di-isopropyl 3-furylboronate to give 6-(3-furyl)-4-[3-methyl-4-(2-pyridylmethoxy)anilino]-quinazoline in 55% yield, m.p. 206°-208° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866572 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-1eac68aaeccc43a5af558243462e4aea |
| Source note | uspto-grants-1999_02 |