HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 361377Generated: October 27, 2026
Sodium Bicarbonate → 3-(2-Cyclopropylethylamino)-5-chloro-6-methyl-1-(benzyloxycarbonylmethyl)-pyrazinone
https://huagongshe.com/reaction/361377
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Benzyl 2-[3,5-dichloro-2-methyl-6-oxo-1(6H)-pyrazinyl]acetate | HCID 10663926 | — |
| Reactant | 2-Cyclopropylethanamine hydrochloride | HCID 21916080 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-(2-Cyclopropylethylamino)-5-chloro-6-methyl-1-(benzyloxycarbonylmethyl)-pyrazinone | HCID 54269425 | — |
Reaction Steps
A mixture of 2-cyclopropylethylamine hydrochloride (73 mg, 0.60 mmol), 1-benzyloxycarbonylmethyl-3,5-dichloro-6-methylpyrazinone (164 mg, 0.50 mmol) and sodium hydrogen carbonate (101 mg, 1.20 mmol) in toluene (1 mL) and water (0.5 mL) was stirred at 80° C. for 3 h. The reaction was then cooled and partitioned between methylene chloride and 10% citric acid solution. The organic layer was dried (Na2SO4) and evaporated in vacuo to give the title compound as a crystalline solid:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05866573 |
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| Source dataset | uspto-grants-1999_02 |
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| ORD ID | ord-99d4b3699ee9434bb6cc22a0691ee632 |
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| Source note | uspto-grants-1999_02 |
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