Acetic Acid → HCID 54160971, compound

Participants

Reaction Steps

A solution of 175 mg (0.75 mmol) of 2-t-butyloxycarbonylamino-4-cyano-3-methylpyridine and 88 μL (1.5 mmol) of acetic acid in 10 mL of MeOH was hydrogenated over 75 mg of 10% Pd-C at 55 psi overnight on a Parr apparatus. The catalyst was removed by filtration, concentrated at reduced pressure, and the residue partitioned between CHCl3 and 10% Na2CO3. The aqueous layer was extracted with CHCl3 and the combined organic layers were dried over Na2SO4 and concentrated to give 150 mg of the title compound as a colorless oil:

Provenance & Evidence