反应详情

2-Methylcyclohexanone (170 mg, 1.52 mmol) was mixed with 1-methyl-3,5-dinitro-2-pyridone (296 mg, 1.49 mmol) in 1M methanolic ammonia (30 mL, 30 mmol) and heated at reflux for 3 h. The solvent was evaporated off and the residue was suspended in CHCl3 and flash chromatographed over silica gel (19 g) eluting with EtOAc/hexane (1:10) to afford a white solid (213 mg, 75% yield): mp 61°-63° C.

1. temperatureheated
2. temperatureat reflux for 3 h
3. customThe solvent was evaporated off
4. customflash chromatographed over silica gel (19 g)
5. washeluting with EtOAc/hexane (1:10)