反应详情

To a suspension of 6.8 g of lithium aluminum hydride in 200 ml of anhydrous ether are added 26.2 g of ethyl 4-(3-pentyloxyphenoxy)butyrate dissolved in 100 ml of anhydrous ether. Addition is carried out at a rate which maintains reflux of the solvent. After 30 minutes, the mixture is cooled in an ice bath and quenched with water. 3N HCl is added; and the organic layer is separated, dried over magnesium sulfate, filtered, and concentrated under vacuum to yield 4-[3-(pentyloxy)phenoxy]butanol.

1. additionAddition
2. temperaturemaintains reflux of the solvent
3. temperaturethe mixture is cooled in an ice bath
4. customquenched with water
5. addition3N HCl is added
6. customand the organic layer is separated
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated under vacuum