Phenethylamine → HCID 67767615, compound

Participants

Reaction Steps

To a solution of (3aR*,10aS*)-9-[4-(phenoxycarbonylamino)benzyl]-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one (0.43 g, 1 mmol) in DMF (5 mL) was added N-benzylmethylamine (0.14 mL, 1.1 mmol) and the mixture was stirred at room temperature for 84 hours. This reaction mixture was diluted with ethyl acetate and washed with 2 portions of water and, then, with saturated aqueous NaCl solution. This solution was dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate=1:1) to provide 0.30 g (yield 66%) of the title compound. Amorphous.

Provenance & Evidence