Phenethylamine → HCID 67767844, compound

Participants

Reaction Steps

To a solution of (3aR*,10aS*)-4-(chloroacetyl)-9-[4-(phenoxycarbonylamino)benzyl]-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one (151 mg, 0.3 mmol) in DMF (1.5 mL) was added 2-phenylethylamine (38 μl, 0.3 mmol) and the mixture was stirred at room temperature for 4 hours. This reaction mixture was diluted with ethyl acetate and washed with 2 portions of water and, then, with saturated aqueous NaCl solution. This solution was dried over NaSO4 and concentrated under reduced pressure and the residue was crystallized from ethanol-diethyl ether to provide 62 mg (yield 39%) of the title compound. m.p. 224°-226° C.

Provenance & Evidence