Benzoyl chloride → HCID 67768061, compound

HRID 361579Notes

Reaction equation

HRID 361579 reaction equation
Br.[NH2:2][C:3]1[CH:4]=[C:5]([CH:36]=[CH:37][CH:38]=1)[CH2:6][N:7]1[C:13](=[O:14])[C@H:12]2[CH2:15][CH2:16][CH2:17][C@H:11]2[N:10]([C:18](=[O:31])[CH2:19][N:20]2[C:24](=[O:25])[C:23]3=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]3[C:21]2=[O:30])[C:9]2[CH:32]=[CH:33][CH:34]=[CH:35][C:8]1=2.[C:39](Cl)(=[O:46])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1>C(OCC)C>[C:39]([NH:2][C:3]1[CH:4]=[C:5]([CH:36]=[CH:37][CH:38]=1)[CH2:6][N:7]1[C:13](=[O:14])[C@H:12]2[CH2:15][CH2:16][CH2:17][C@H:11]2[N:10]([C:18](=[O:31])[CH2:19][N:20]2[C:24](=[O:25])[C:23]3=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]3[C:21]2=[O:30])[C:9]2[CH:32]=[CH:33][CH:34]=[CH:35][C:8]1=2)(=[O:46])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 67767678HCID 67767678, compound

Product 1

HCID 67768061HCID 67768061, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using (3aR*,10aS*)-9-(3-aminobenzyl)-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one hydrobromide and benzoyl chloride, the title compound was synthesized in otherwise the same manner as Example 20. Yield 56%, m.p. 244°-246° C. (diethyl ether).

Sources & evidence

ORD record
ord-2acb18e40ebf43ebbfb726bb5426dade
Source dataset
uspto-grants-1999_02
Patent number
US05866567

Reaction notes

Loading…