Benzyl isocyanate → (3aR*,10aS*)-9-[4-(3-benzylureido)benzyl]-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one

Participants

Reaction Steps

To a solution of (3aR*,10aS*)-9-(4-aminobenzyl)-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one (148 mg, 0.3 mmol) in dichloromethane (4 mL) was added benzyl isocyanate (40 μL, 0.32 mmol) and the mixture was stirred at room temperature for 90 hours. After filtration, the reaction product was rinsed with diethyl ether to provide 118 mg (yield 63%) of the title compound. m.p. 169°-171° C.

Provenance & Evidence