HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(-)-1-Phenylethyl isocyanate → (3aR*,10aS*)-9-[4-[3-((S)-1-Phenylethyl)ureido]-benzyl]-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(-)-1-Phenylethyl isocyanate | HCID 2724173 | — |
| Reactant | (3aR*,10aS*)-9-(4-aminobenzyl)-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][l,4]diazepin-10(1H)-one | HCID 54523300 | — |
| Solvent | Diethylether ethylacetate | HCID 21584169 | — |
| Product | (3aR*,10aS*)-9-[4-[3-((S)-1-Phenylethyl)ureido]-benzyl]-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one | HCID 54385287 | 53% |
Reaction Steps
Using (3aR*,10aS*)-9-(4-aminobenzyl)-4-(phthalimidoacetyl)-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one and (S)-1-phenylethyl isocyanate, the title compound was synthesized in otherwise the same manner as Example 26. Yield 53%, m.p. 156°-160° C. (ethyl acetate-diethyl ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866567 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-fefd29582047411aa5f2f55c8bc8e804 |
| Source note | uspto-grants-1999_02 |