D-Tartaric acid → HCID 86753649, compound

Participants

Reaction Steps

A solution of 22.2 g of (RS)-1-pyridin-2-yl-1,2,3,4-tetrahydro-isoquinoline in 500 ml of warm absolute ethanol was treated with 15.85 g of D-(-)-tartaric acid. After filtration of the slightly turbid solution, the clear solution obtained was left to stand at 20° C. for 6 h. and at 5° C. for a further 18 h. The precipitate formed was filtered off under suction and washed with absolute ethanol. A second crystallizate was obtained immediately from the mother liquor. The precipitates were combined (15.0 g, m.p. 155°-158° C.) and recrystallized from 900 ml of absolute ethanol. There were obtained 11.4 g of (R)-1-pyridin-2-yl-1,2,3,4-tetrahydro-isoquinoline (2S,3S)-2,3-dihydroxy-succinate (1:1) as a colorless product, m.p. 162°-165° C.

Provenance & Evidence