Acetyl chloride → HCID 136132506, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.8 g (3.3 mmol) of methyl 3-(hydroxyiminomethyl)-4,7-dimethylindole-2-carboxylate in 15 ml of anhydrous THF was cooled to 0° C., and then 0.5 ml (3.6 mmol) of triethylamine was added. While the reaction mixture was stirred at 0° C., a solution of 0.25 ml (3.6 mmol) of acetyl chloride in 5 ml of THF was added dropwise over a period of 15 minutes. The reaction mixture was stirred at room temperature for 1 hour and then poured into 100 ml of ice water. The crystals were separated by filtration and dried to provide 0.85 g of yellow crystals.

Provenance & Evidence