Methyl Isocyanate → HCID 54370936, compound

Participants

Reaction Steps

A mixture of 0.6 g (2.75 mmol) of methyl 3-amino-4,7-dimethylindole-2-carboxylate, one drop of pyridine and 15 ml of anhydrous THF was prepared and 5.0 ml of methyl isocyanate was added dropwise at 0° C. The reaction mixture was stirred at room temperature for 2.5 hours. The crystals precipitated were separated by filtration, washed with ethyl acetate and air-dried to provide 180 mg of white crystals. Yield: 24%

Provenance & Evidence