反应详情

119 g of 2-bromo-1-[4-methylthiophenyl]ethanone (prepared according to J. Amer. Chem. Soc., 1952, p. 5475) are dissolved in a mixture of 200 ml of methanol and 300 ml of acetone. 53 g of potassium formate are added and the mixture is heated under reflux for 4 hours. The organic solvents are evaporated, the residual oil is taken up with ethyl acetate and washed with a saturated solution of sodium chloride. The ethyl acetate is evaporated and the residual oil crystallises in isopropyl ether.

1. temperaturethe mixture is heated
2. temperatureunder reflux for 4 hours
3. customThe organic solvents are evaporated
4. washwashed with a saturated solution of sodium chloride
5. customThe ethyl acetate is evaporated
6. customthe residual oil crystallises in isopropyl ether