Phenol → 4-Acetamido-2-but-2-enylphenol
Reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])[CH:2]=[CH:3][CH3:4].[C:12]1(O)[CH:17]=CC=[CH:14][CH:13]=1.C(OC(=O)C)(=O)C.[C:26]([NH:29][C:30]1[CH:35]=[C:34](Cl)[C:33]([OH:37])=[C:32](Cl)[CH:31]=1)(=[O:28])[CH3:27].NC1C=C(Cl)C(O)=C(Cl)C=1>>[NH2:29][C:9]1[CH:8]=[CH:7][C:6]([OH:11])=[C:5]([CH2:1][CH:2]=[CH:3][CH3:4])[CH:10]=1.[C:26]([NH:29][C:30]1[CH:35]=[CH:34][C:33]([OH:37])=[C:32]([CH2:17][CH:12]=[CH:13][CH3:14])[CH:31]=1)(=[O:28])[CH3:27]Participants
7
Procedure
Similarly 4-amino-2-but-2-enyl phenol (used as starting material in Example 40) was prepared from 2-but-2-enylphenol. Treatment of this phenol with acetic anhydride (using the method described above for the preparation of 4-acetamido-2,6-dichlorophenol from 4-amino-2,6-dichlorophenol) gave 4-acetamido-2-but-2-enylphenol.
Sources & evidence
- ORD record
- ord-5da26fae619545109a3027e001b388d8
- Source dataset
- uspto-grants-1999_02
- Patent number
- US05866611
Reaction notes
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