1-Azido-4-(butoxycarbonylamino)but-2-yne → HCID 178419546, compound

HRID 361733Notes

Reaction equation

[BrH:1].Br.[NH2:3][CH2:4][C:5]#[C:6][CH2:7][NH:8][C:9](=[NH:12])[CH2:10][F:11].N(CC#CCN[C:21]([O:23][CH2:24][CH2:25][CH2:26][CH3:27])=[O:22])=[N+]=[N-].Br.C(SC(=N)CF)C1C=CC=CC=1>>[BrH:1].[CH2:24]([O:23][C:21]([NH:3][CH2:4][C:5]#[C:6][CH2:7][NH:8][C:9](=[NH:12])[CH2:10][F:11])=[O:22])[CH2:25][CH2:26][CH3:27]

Participants

Reactant 3

HCID 183565361-Azido-4-(butoxycarbonylamino)but-2-yne

HCID 69471538HCID 69471538, compound

HCID 178419269HCID 178419269, compound

Product 1

HCID 178419546HCID 178419546, compound

Procedure

1-Amino-4-(1-imino-2-fluoroethylamino)but-2-ynedihydrobromide was made from 1-azido-4-(butoxycarbonylamino)but-2-yne and S-benzyl-2-fluorothioacetimidate hydrobromide to yield 1-butoxycarbonylamino-4-(1-imino-2-fluoro-ethylamino) but-2-yne hydrobromide as an intermediate.

Sources & evidence

ORD record: ord-98deb0e51d6840c4bd522acb93abdb03
Source dataset: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05866612

Reaction notes

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