HRID361757

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID23511620

tert-Butyl (piperidin-4-yl)acetate

C11H21NO2

结构：CC(C)(C(=O)O)C(C=Cc1ccccc1)NC(=O)c1ccc(C#N)cc1

HCID70202156

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)CC1CCN(C(=O)C(C)(C)C(C=Cc2ccccc2)NC(=O)c2ccc(C#N)cc2)CC1

HCID86753670

未命名化合物

收率 30.3%

PROCEDURE

实验过程

The same procedure as in Example 2-(6-2) was performed with N-4-cyanobenzoyl-β-styryl-α,α-dimethyl-β-alanine (100 mg, 0.287 mmol) using 4-piperidineacetic acid t-butyl ester (203 mg, 0.86 mmol) to yield an oil of N-4-cyanobenzoyl-β-styryl-α,α-dimethyl-β-alanyl-4-piperidineacetic acid t-butyl ester (46 mg, 30.3%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3e33cfa670743008f22964119bf8c27
来源数据集: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05866592
来源说明: uspto-grants-1999_02

反应 SMILES

[C:1]([C:3]1[CH:26]=[CH:25][C:6]([C:7]([NH:9][CH:10]([CH:17]=[CH:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:11]([CH3:16])([CH3:15])[C:12](O)=[O:13])=[O:8])=[CH:5][CH:4]=1)#[N:2].[C:27]([O:31][C:32](=[O:40])[CH2:33][CH:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)([CH3:30])([CH3:29])[CH3:28]>>[C:27]([O:31][C:32](=[O:40])[CH2:33][CH:34]1[CH2:39][CH2:38][N:37]([C:12](=[O:13])[C:11]([CH3:16])([CH3:15])[CH:10]([CH:17]=[CH:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[NH:9][C:7](=[O:8])[C:6]2[CH:25]=[CH:26][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:36][CH2:35]1)([CH3:30])([CH3:28])[CH3:29]