Benzyl piperazin-1-ylacetate → N-4-cyanobenzoyl-beta-phenyl-alpha,alpha-dimethyl-beta-alanyl-4-piperazineacetic acid benzyl ester

HRID 361762Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 361762
[C:1]([C:3]1[CH:24]=[CH:23][C:6]([C:7]([NH:9][CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=O)=[O:8])=[CH:5][CH:4]=1)#[N:2].[CH2:25]([O:32][C:33](=[O:41])[CH2:34][N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:25]([O:32][C:33](=[O:41])[CH2:34][N:35]1[CH2:36][CH2:37][N:38]([C:12](=[O:14])[C:11]([CH3:16])([CH3:15])[CH:10]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[NH:9][C:7](=[O:8])[C:6]2[CH:23]=[CH:24][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:39][CH2:40]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Komponenten

3

Edukt 2

HCID 18423308Benzyl piperazin-1-ylacetateHCID 70199446N-4-cyanobenzoyl-beta-phenyl-alpha,alpha-dimethyl-beta-alanine

Produkt 1

HCID 86753675N-4-cyanobenzoyl-beta-phenyl-alpha,alpha-dimethyl-beta-alanyl-4-piperazineacetic acid benzyl esterAusbeute 71,9 %

Versuchsvorschrift

The same procedure as in Example 2-(6-2) was performed with N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanine (0.4 g, 1.24 mmol) and piperazineacetic acid benzyl ester (0.87 g, 3.72 mmol) to yield an oil of N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanyl-4-piperazineacetic acid benzyl ester (0.48 g, 70.0%).

Quellen und Nachweise

ORD-Eintrag
ord-9cc90c3a9f09425c8baf43a68fd29469
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05866592

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