Acetic Acid → HCID 86753683, compound

Participants

Reaction Steps

The compound of Example 69, i.e. benzyl-N-(N-(4-(4-morpholinoimidoyl)benzoyl-β-phenyl-α,α-dimethyl-β-alanyl)-4-piperidineacetate (54 mg, 0.086 mmol) was dissolved in a 80% aqueous methanol solution (10 ml) containing 2% acetic acid. To the resulting solution was added 5% palladium carbon (10 mg) and the mixture was stirred overnight under a hydrogen atmosphere. After the solvent was distilled off, the residue was dissolved in a 1N aqueous solution of acetic acid and purified by HPLC in the same manner as in Example 44 to yield the titled compound (32 mg, 69%).

Provenance & Evidence