Pyrrolidine → HCID 86753685, compound

Participants

Reaction Steps

N-Boc-β-ethyl-α,α-dimethyl-β-alanine was condensed with 4-piperidineacetic acid methyl ester in the same manner as in Example 43 to yield N-(N-β-ethyl-α,α-dimethyl-β-alanyl)-4-piperidineacetic acid methyl ester. From the resulting compound, methyl-N-(N-(4-cyano-2-fluorobenzoyl)-β-ethyl-α,α-dimethyl-β-alanyl)-4-piperidineacetate was derived in the same manner as in Example 45. The same procedure as in Example 45 was performed with this compound (1.0 g, 2.3 mmol) by using pyrrolidine (1.9 ml) as an amine to yield the titled compound (248 mg, 21%).

Provenance & Evidence