HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → N-t-butyloxycarbonyl-alpha-isopropyl-beta-alanine t-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | 3-Tert-butoxycarbonylamino-propionic acid tert-butyl ester | HCID 54096617 | — |
| Product | N-t-butyloxycarbonyl-alpha-isopropyl-beta-alanine t-butyl ester | HCID 86753688 | 42% |
Reaction Steps
N-t-Butyloxycarbonyl-β-alanine t-butyl ester (2.0 g) was isopropylated by the same procedure as in Comparative Example 4-(1) using isopropyl iodide (1.8 ml) to yield an oil of N-t-butyloxycarbonyl-α-isopropyl-β-alanine t-butyl ester (990 mg, 42%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866592 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-a2736c7a52a24d8ba4a1a8f2bbefc422 |
| Source note | uspto-grants-1999_02 |