Isopropyltriphenylphosphonium iodide → 1-Benzyl-4-[N-ethyl-N-(3-(2-methyl-1-propenyl)-2-pyridinyl)amino]piperidine

Participants

Reaction Steps

Following the general procedure of EXAMPLE 16 and making non-critical variations but starting with n-butyl lithium (1.6M, 4.3 ml, 6.8 mmol), isopropyltriphenylphosphonium iodide (2.9 g, 6.8 mmol), and 1-benzyl-4-[N-ethyl-N-(3-(formyl)-2-pyridinyl)amino]piperidine (XXI, EXAMPLE 12, 1.1 g, 3.4 mmol), the title compound is obtained, NMR (300 MHz, CDCl3) 1.08, 1.71-1.80, 1.90, 1.90-2.00, 2.01, 2.98-3.03, 3.30-3.45, 3.43, 3.57, 6.18, 6.89, 7.32-7.45, 7.46 and 8.24δ.

Provenance & Evidence