HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-tert-Butoxycarbonyl-4-[N-methyl-N-(3-(formyl)-2-pyridinyl)amino]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Bromonicotinaldehyde | HCID 4714951 | — |
| Reactant | tert-Butyl 4-(methylamino)piperidine-1-carboxylate | HCID 15380702 | — |
| Product | 1-tert-Butoxycarbonyl-4-[N-methyl-N-(3-(formyl)-2-pyridinyl)amino]piperidine | HCID 10495874 | — |
Reaction Steps
Following the general procedure of EXAMPLE 12 and making non-critical variations but starting with 2-bromo-3-formylpyridine (XVI, EXAMPLE 1, 2.67 g, 14.4 mmol), 1-tert-butoxycarbonyl-4-methylaminopiperidine (XIII, 2.8 g, 13.1 mmol), and diisopropylethylamine (2.3 ml), the title compound is obtained, mp 90°-91°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866589 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-fc54829d51c7473db70750a1eeb56143 |
| Source note | uspto-grants-1999_02 |