Isopropyltriphenylphosphonium iodide → 1-tert-Butoxycarbonyl-4-[N-methyl-N-(3-(2-methyl-1-propenyl)-2-pyridinyl)amino]piperidine

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Reaction Steps

Following the general procedure of EXAMPLE 16 and making non-critical variations but starting with n-butyl lithium (1.6M, 3.9 ml, 6.26 mmol), isopropyltriphenylphosphonium iodide (2.71 g, 6.26 mmol), and 1-tert-butoxycarbonyl-4-[N-methyl-N-(3-(formyl)-2-pyridinyl)amino]piperidine (XXIV, EXAMPLE 26) (1.0 g, 3.13 mmol), the title compound is obtained, NMR (300 MHz, CDCl3) 1.30, 1.50-1.59, 1.64, 1.75, 2.42-2.50, 2.61, 3.40-3.50, 3.95-4.06, 5.88, 6.62, 7.18 and 7.95δ.

Provenance & Evidence