HCID 67576728, compound → HCID 10762096, compound

Participants

Reaction Steps

To a mixture of 1-[1,1-dimethylethoxycarbonyl]-4-[N-methyl-N-(3-(1,1-dimethylprop-2-enylamino)-2-pyridinyl)amino]piperidine (EXAMPLE 62, 2.41 g) in absolute ethanol (40 ml) under nitrogen is added wet Raney Nickel (620 mg). The mixture is put under a hydrogen atmosphere at 40 psi for 21 hrs, filtered through diatomaceous earth, and concentrated to give an oil which is chromatographed (silica gel, 70-230 mesh, 250 g; eluting with a gradient of ethyl acetate/hexane (10/90-35/65)), to give the title compound, NMR (CDCl3) 7.67, 7.04, 6.87, 4.87, 4.04, 3.20, 2.76, 2.61, 1.71, 1.50, 1.45, 1.31 and 0.86δ.

Provenance & Evidence