HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-nitropyridine → 1-benzyl-4-[N-propyl-N-(3-nitro-2-pyridinyl)amino]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| Reactant | 1-benzyl-N-methylpiperidin-4-amine | HCID 4136128 | — |
| Reactant | 2-Bromo-3-ethoxypyridine | HCID 10631926 | — |
| Product | 1-benzyl-4-[N-propyl-N-(3-nitro-2-pyridinyl)amino]piperidine | HCID 11792454 | — |
Reaction Steps
Following the general procedure of EXAMPLE 70, and making non-critical variations but substituting 1-benzyl-4-(propylamino)piperidine (EXAMPLE 112) for 1-benzyl-4-(methylamino)piperidine and 2-chloro-3-nitropyridine for 2-bromo-3-ethoxypyridine and using a reaction time of 10 min, the title compound is obtained, C,H,N: Anal. Calcd for C20H26N4O2 : C=67.77, H=7.39, N=15.81-found: C=67.44, H=7.42, N=15.60.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866589 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-a91f023ed8034f7186155f02e677ce60 |
| Source note | uspto-grants-1999_02 |