Ethyl acetate hexane → HCID 67576838, compound

HRID 361843Notes

Reaction equation

HRID 361843 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]([CH2:23][CH3:24])[C:16]2[C:21]([NH2:22])=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OCC)(=O)C.[CH3:31][CH2:32][CH2:33]CCC>>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]([CH2:23][CH3:24])[C:16]2[C:21]([NH:22][CH:32]([CH3:33])[CH3:31])=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21226206Ethyl acetate hexaneHCID 54076407HCID 54076407, compound

Product 1

HCID 67576838HCID 67576838, compound

Procedure

Following the general procedure of EXAMPLE 201 and making non-critical variations, but using 1-benzyll-4-[N-ethyl-N-(3-amino-2-pyridinyl)amino]methylpiperidine (EXAMPLE 177, 8.78 g, 27.06 mmol), and chromatographing the crude product (silica gel; ethyl acetate/hexane (50/50)) gives the title compound, NMR (300 MHz, CD3OD) 7.52, 7.21, 6.93, 3.56, 3.42, 2.90, 2.81, 1.86, 1.64, 1.33, 1.22, 1.+w and 0.95δ.

Sources & evidence

ORD record
ord-3e3c697a6fc646c99db49904641d2acc
Source dataset
uspto-grants-1999_02
Patent number
US05866589

Reaction notes

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