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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 361849Generated: October 29, 2026

1-Benzyl-4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)amino]methylpiperidine → 4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)aminomethyl]piperidine

https://huagongshe.com/reaction/361849

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Benzyl-4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)amino]methylpiperidineHCID 54316346—
ReactantHCID 178418361HCID 178418361—
CatalystPalladium hydroxideHCID 9942167—
SolventEthanolHCID 702—
Product4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)aminomethyl]piperidineHCID 54233645—

Reaction Steps

1-Benzyl-4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)aminomethyl]piperidine (EXAMPLE 187, 2.38, 6.75 mmol) and palladium hydroxide on carbon (1.5 g) in 100 ml ethanol is hydrogenated under 40 p.s.i. hydrogen for 42 hr. Filtration and evaporation of the solvent gives 4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)aminomethyl]piperidine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05866589
Source datasetuspto-grants-1999_02
ORD IDord-4d06c99cc1834823830127c4970f4dd3
Source noteuspto-grants-1999_02