HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrole-2-Carboxylic Acid → 1-(Pyrrole-2-carbonyl)-4-[N-ethyl-N-(3-ethylamino-2-pyridinyl) amino]methylpiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrole-2-Carboxylic Acid | HCID 12473 | — |
| Reactant | 4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)aminomethyl]piperidine | HCID 54233645 | — |
| Product | 1-(Pyrrole-2-carbonyl)-4-[N-ethyl-N-(3-ethylamino-2-pyridinyl) amino]methylpiperidine | HCID 53880282 | — |
Reaction Steps
Following the general procedure of EXAMPLE 149 and making non-critical variations, but using pyrrole-2-carboxylic acid (823 mg, 7.40 mmol) and 4-[N-ethyl-N-(3-ethylamino-2-pyridinyl)aminomethyl]piperidine (970 mg, 3.70 mmol), a crude product is obtained. Chromatography [with 40-100% ethyl acetate/hexane], followed by crystallization from ether/hexane gives the title compound, mp=109°-110°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866589 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-cf4487aa3ab64ba8a66789ce75327117 |
| Source note | uspto-grants-1999_02 |