1-Benzyl-4-[N-ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine → 4-[N-Ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine

Participants

Reaction Steps

1-Benzyl-4-[N-ethyl-N-(6-fluoro-3-(isopropylamino)-2-pyridinyl)amino]piperidine (EXAMPLE 196, 2.1 g, 5.76 mmol) is dissolved in ethanol (100 ml) and 0.96 g of palladium hydroxide is added. The reaction is placed on a Parr hydrogenator at 40 psi for 12 hr. Then the reaction is filtered through diatomaceous earth, concentrated under reduced pressure, and used without further purification, NMR (300 MHz, CDCl3) 6.93, 6.55, 4.32, 3.51, 3.11, 3.10-2.95, 2.59, 1.77, 1.55, 1.18 and 0.86δ.

Provenance & Evidence