1,1'-(Chlorophenylmethylene)bis(4-methoxybenzene) → HCID 18705555, compound

HRID 361875Notes

Reaction equation

HRID 361875 reaction equation
[OH:1][N:2]1[CH:5]([CH2:6][OH:7])[CH:4]([N:8]2[CH:16]=[N:15][C:14]3[C:9]2=[N:10][CH:11]=[N:12][C:13]=3[NH:17][C:18](=[O:25])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:3]1=[O:26].[CH3:27][O:28][C:29]1[CH:50]=[CH:49][C:32]([C:33](Cl)([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C:34]2[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=2)=[CH:31][CH:30]=1>N1C=CC=CC=1>[OH:1][N:2]1[CH:5]([CH2:6][O:7][C:33]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)([C:34]2[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=2)[C:32]2[CH:31]=[CH:30][C:29]([O:28][CH3:27])=[CH:50][CH:49]=2)[CH:4]([N:8]2[CH:16]=[N:15][C:14]3[C:9]2=[N:10][CH:11]=[N:12][C:13]=3[NH:17][C:18](=[O:25])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:3]1=[O:26]

Participants

4

Reactant 2

HCID 968311,1'-(Chlorophenylmethylene)bis(4-methoxybenzene)HCID 18705557HCID 18705557, compound

Product 1

HCID 18705555HCID 18705555, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-N-Hydroxy-3-(N-benzoyladenin-9-yl)-4-hydroxymethyl-2-azetidinone (10 mmole) is dissolved in pyridine (20 ml) and 4,4'-dimethoxytrityl chloride (12 mmole) is added and stirred under argon for 8 hours. The reaction mixture is concentrated under reduced pressure. The crude product is purified by flash chromatorgraphy using silica gel and ethyl acetate/dichloromethane/1% triethylamine as eluants to give the title compound.

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customThe crude product is purified by flash chromatorgraphy

Sources & evidence

ORD record
ord-e7387d54f02d436cbb14a63563f43c37
Source dataset
uspto-grants-1999_02
Patent number
US05866691

Reaction notes

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