1,3-Propanediol → 3-[(Tert-butyldimethylsilyl)oxy]propan-1-ol

Participants

Reaction Conditions

Reaction Steps

To a suspension of sodium hydride (0.1 mole) in anhydrous tetrahydrofuran (200 ml) cooled to 0° C. with stirring under an atmosphere of nitrogen is added a solution of 1,3-dihydroxypropane (0.1 mole) in tetrahydrofuran (150 ml) slowly over a period of 1 hour. Then a solution of tert-butyldimethylsilyl chloride (0.1 mole) in tetrahydrofuran (150 ml)is added slowly over a period of 1 hour. Stirring is continued for 6 hours.The mixture is then diluted with ethyl acetate (400 ml), washed with water (100 ml), brine (75 ml), dried and concentrated to afford the title compound.

Provenance & Evidence