反应详情

21.0 g of 2-acetyl-5-benzofurancarbonitrile was dissolved in 300 ml of dichloromethane. With stirring at a temperature of -10° C., 30 ml of dichloromethane solution containing 18.2 g of bromine was added dropwise to the above solution. After gradually warming up to ice-cold temperature, the resulting reaction solution was mixed with chloroform and washed with 10% sodium thiosulfate aqueous solution. After drying the organic layer and subsequent concentration to dryness, the resulting residue was recrystallized from a benzene/n-hexane mixture to obtain 21.0 g of 2-(2-bromo-1-oxoethyl)-5-benzofurancarbonitrile in the form of colorless crystals.

1. additionwas added dropwise to the above solution
2. temperatureAfter gradually warming up to ice-cold temperature
3. customthe resulting reaction solution
4. washwashed with 10% sodium thiosulfate aqueous solution
5. customAfter drying
6. concentrationthe organic layer and subsequent concentration to dryness
7. customthe resulting residue was recrystallized from a benzene/n-hexane mixture