Ethanol → HCID 86750020, compound

HRID 361944Notes

Reaction equation

HRID 361944 reaction equation
[ClH:1].Cl.[C:3]([C:6]1[CH:7]=[CH:8][C:9]2[O:13][C:12]([CH2:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][C@H:23]4[CH2:27][CH2:26][NH:25][CH2:24]4)=[CH:18][C:17]=3[O:28][CH2:29][C:30]([OH:32])=[O:31])=[CH:11][C:10]=2[CH:33]=1)(=[NH:5])[NH2:4].S(Cl)([Cl:36])=O.[CH2:38](O)[CH3:39]>>[ClH:36].[ClH:1].[C:3]([C:6]1[CH:7]=[CH:8][C:9]2[O:13][C:12]([CH2:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][C@H:23]4[CH2:27][CH2:26][NH:25][CH2:24]4)=[CH:18][C:17]=3[O:28][CH2:29][C:30]([O:32][CH2:38][CH3:39])=[O:31])=[CH:11][C:10]=2[CH:33]=1)(=[NH:4])[NH2:5]

Participants

4

Reactant 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 70075614HCID 70075614, compound

Product 1

HCID 86750020HCID 86750020, compound

Procedure

0.65 g of [2-[2-(5-amidino-2-benzofuranyl)ethyl]-5-[((3S)-3-pyrrolidinyl)oxy]phenyl]oxyacetic acid dihydrochloride was dissolved in 50 ml of ethanol. 0.2 ml of thionyl chloride was added to the above solution with ice cooling, and the resulting mixture was stirred at room temperature for 18 hours. Thereafter, the resulting reaction solution was concentrated to dryness, dissolved once in water, and then concentrated again to dryness. In this way, 0.65 g of the title compound was obtained in a solid form.

Workup

  1. customThereafter, the resulting reaction solution
  2. concentrationwas concentrated to dryness
  3. dissolutiondissolved once in water
  4. concentrationconcentrated again to dryness

Sources & evidence

ORD record
ord-e3298f2edbc64d4bbe8cf7972f8bd29b
Source dataset
uspto-grants-1999_02
Patent number
US05866577

Reaction notes

Loading…