HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzoyl chloride → HCID 19939478, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Reactant | 4''-[3-Butyl-1-(2-chloro-phenyl)-5-oxo-1,5-dihydro-[1,2,4]triazol-4-ylmethyl]-biphenyl-2-sulfonic acid amide | HCID 10028815 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 19939478 | HCID 19939478 | 80% |
Reaction Steps
By the procedure of Example 13, Step C, 5-n-butyl-2-(2-chlorophenyl)-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one (from Example 13, Step B) was reacted with 4-fluorobenzoyl chloride. Column chromatography on silica gel (gradient elution with 0.5-5% MeOH in CH2Cl2) afforded an 80% yield of the title compound as cream-colored crystals, mp 118°-120° C., satisfactory purity by TLC in 9:1 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 619 (M+1)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05411980 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-247014b10f43438ca0dd1253774674f2 |
| Source note | uspto-grants-1995_05 |