HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethyl)phenylhydrazine → 5-n-Butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethyl)phenylhydrazine | HCID 520800 | — |
| Reactant | ethyl N-carbethoxyvalerimidate | HCID 53930077 | — |
| Product | 5-n-Butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one | HCID 135527027 | 66% |
Reaction Steps
Ethyl-N-carbethoxyvalerimidate (from Example 4, Step B) was reacted with 2-(trifluoromethyl)phenylhydrazine according to the procedure of Example 4, Step C. Flash chromatography of the crude product on silica gel (gradient elution with 0.5-2% MeOH in CH2Cl2) gave a 66% yield of the title compound as white crystals, mp 124°-126° C.; homogeneous by TLC in 19:1 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 286 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05411980 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-f003449a7d764dffa16cac6627661d60 |
| Source note | uspto-grants-1995_05 |