HCID 22942179, compound → HCID 22942182, compound

Participants

Reaction Steps

Cbz-L-tert-leucine-N-2-(2-methoxyethoxy)ethylamide (7.66 g, 20.9 mmol) was dissolved in ethanol (100 ml) under an argon atmosphere and 10% Palladium on charcoal (1 g) was added as a slurry in ethanol (30 ml). The mixture was placed under an atmosphere of hydrogen as and left to stir overnight at room temperature. TLC analysis revealed that no starting material remained. The flask was purged with argon and the catalyst was removed by filtration. The solvent was removed under reduced pressure to provide L-tert-leucine-N-2-(2-methoxyethoxy)ethylamide as a colourless oil (4.55 g, 94%). 1H--NMR; δ(CDCI3), 6.95 (1H, br s), 3.60-3.40 (8H, m), 3.34 (3H, s), 3.01 (1H, s), 1.61 (2H, br s) and 0.95 (9H, s).

Provenance & Evidence