Acetic Acid → HCID 53871196, compound

Participants

Reaction Conditions

Reaction Steps

Into a four-necked flask were charged 52.3 parts of 2,6-bis(4-hydroxy-3-methylbenzyl)-4-methylphenol, 21.6 parts of sodium hydroxide, 900 parts of water and 100 parts of tetrahydrofurane and they were completely dissolved. While stirring at 40° C., 73.0 parts of 37% formaldehyde was added dropwise thereto and the reaction was conductedfor 6 hours. After completion of the reaction, 36.0 parts of acetic acid was added for neutralization and then the mixture was cooled to 25°C. Thereafter, the precipitated crystalline product was filtered out and rinsed with 1000 parts of deionized water. The filtered product was dried a whole day and night under reduced pressure at 45° C. to obtain 55.1 parts of 2,6-bis(4-hydroxy-3-hydroxymethyl-5-methylbenzyl)-4-methylphenol.

Provenance & Evidence