Acetic Acid → HCID 54471756, compound

Participants

Reaction Conditions

Reaction Steps

Into a four-necked flask were charged 54.4 parts of 2,4-bis(4-hydroxy-3-methylbenzyl)-3,6-dimethylphenol, 21.6 parts of sodiumhydroxide, 900 parts of water and 100 parts of tetrahydrofurane and they were completely dissolved. While stirring at 40° C., 73.0 parts of 37% formaldehyde was added dropwise thereto and the reaction was conductedfor 6 hours. After completion of the reaction, 36.0 parts of acetic acid was added for neutralization and then the mixture was cooled to 25°C. Thereafter,the precipitated crystalline product was filtered out and rinsed with 1000 parts of deionized water. The filtered product was dried a whole day and night under reduced pressure at 45° C. to obtain 56.4 parts of 2,4-bis(4-hydroxy-3-hydroxymethyl-5-methylbenzyl)-3,6-dimethylphenol.

Provenance & Evidence