Cyclopropanecarbonyl chloride → 4''-[3-Butyl-5-oxo-1-(2-trifluoromethyl-phenyl)-1,5-dihydro-[1,2,4]triazol-4-ylmethyl]-biphenyl-2-sulfonic acid cyclopropanecarbonyl-amide

Beteiligte Stoffe

Reaktionsschritte

Following the procedure of Example 13, Step C, 5-n-butyl-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Example 16, Step C) was reacted with cyclopropanecarbonyl chloride. Flash chromatography of the crude product on silica gel (gradient elution with 0.3-1% MeOH in CH2Cl2) gave a 51% yield of the title compound as white crystals, mp 187°-189° C.; satisfactory purity by TLC in 19:1 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 599 (M+1)+.

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