反应详情

Following a procedure similar to that described in Preparation 4, but using 2.10 g of (2S,4S)-4-(4-methoxy-benzylthio)-2-(1-homopiperazinylcarbonyl)-1-(4-nitro-benzyloxycarbonyl)pyrrolidine hydrochloride [prepared as described in Preparation 2(i)] and 0.93 g of N-(4-nitrobenzyloxycarbonyl)formamidine, 2.38 g of the trifluoromethanesulfonate of the title compound were obtained. The salt was treated by the same procedure as described in Preparation 4(ii), to give 1.90 g of the title compound.

1. customthat described in Preparation 4