HRID362044

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11788288

(Piperazin-2-yl)methanol

C5H12N2O

结构：COc1ccc(CS[C@H]2C[C@@H](C(=O)O)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1

HCID15297071

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CS[C@H]2C[C@@H](C(=O)N3CCNC(CO)C3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1

HCID57158023

未命名化合物

收率 56.6%

PROCEDURE

实验过程

Following a procedure similar to that described in Preparation 8, but using 10.0 g of (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid, 4.4 g of N,N'-carbonyldiimidazole and 4.0 g of 2-hydroxymethylpiperazine, 6.9 g of the title compound were obtained, as a powder.

WORKUP

后处理

customthat described in Preparation 8

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eed6d9c61d834727a20f1d86b7fa8fed
来源数据集: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05866564
来源说明: uspto-grants-1999_02

反应 SMILES

[CH3:1][O:2][C:3]1[CH:31]=[CH:30][C:6]([CH2:7][S:8][C@@H:9]2[CH2:13][N:12]([C:14]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=3)=[O:15])[C@H:11]([C:27]([OH:29])=O)[CH2:10]2)=[CH:5][CH:4]=1.[OH:32][CH2:33][CH:34]1[CH2:39][NH:38][CH2:37][CH2:36][NH:35]1>>[OH:32][CH2:33][CH:34]1[NH:35][CH2:36][CH2:37][N:38]([C:27]([C@@H:11]2[CH2:10][C@H:9]([S:8][CH2:7][C:6]3[CH:30]=[CH:31][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[CH2:13][N:12]2[C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=2)=[O:15])=[O:29])[CH2:39]1